Zolmitriptan
Zolmitriptan
Zolmitriptan
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2663-10MG | Zolmitriptan | 10mg | $105.00 | |
| GBM-2663-50MG | Zolmitriptan | 50mg | $420.00 |
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Description
Serotonin 5HT1b/1d agonist; Regenerative activity
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Specifications
Bioassays Specification Bio-Activity Serotonin 5HT1b/1d agonist; Regenerative activity Chemical Name (4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone Function / Pharmacology Potent and selective serotonin 5HT 1B/1D agonist (Ki=0.63 and 5.01 nM for 5HT 1D and 1B respectively.1 Displays proven efficacy for the treatment of migraine.2 Inhibits neurogenic inflammation and pain during electrical stimulation in human skin.3 Induces nerve growth, integration and function in transplanted heterologous organs in regenerative medicine.4 CAS# 139264-17-8 MW 287.36 Molecular Formula C16H21N3O2 Solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Supplied powder Storage as supplied -20°C Ship temp Ambient References 1) Pauwels et al. (1997), How efficacious are 5-HTB/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines; Pharmacol., 36 499 2) Martin et al. (1997), Receptor specificity and trigemino-vascular inhibitor actions of a novel 5HT1B/1D receptor partial agonist, 311C90 (zolmitriptan); Br. J. Pharmacol., 121 157 3) Doring et al. (2015), Zolmitriptan inhibits neurogenic inflammation and pain during electrical stimulation in human skin; Eur. J. Pain, 19 966 4) Blackiston et al. (2017), Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity; Regenerative Med., 2 8 Antibody Specification Alternate Names BW 311C90 Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | Serotonin 5HT1b/1d agonist; Regenerative activity |
| Chemical Name | (4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone |
| Function / Pharmacology | Potent and selective serotonin 5HT 1B/1D agonist (Ki=0.63 and 5.01 nM for 5HT 1D and 1B respectively.1 Displays proven efficacy for the treatment of migraine.2 Inhibits neurogenic inflammation and pain during electrical stimulation in human skin.3 Induces nerve growth, integration and function in transplanted heterologous organs in regenerative medicine.4 |
| CAS# | 139264-17-8 |
| MW | 287.36 |
| Molecular Formula | C16H21N3O2 |
| Solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Pauwels et al. (1997), How efficacious are 5-HTB/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines; Pharmacol., 36 499 2) Martin et al. (1997), Receptor specificity and trigemino-vascular inhibitor actions of a novel 5HT1B/1D receptor partial agonist, 311C90 (zolmitriptan); Br. J. Pharmacol., 121 157 3) Doring et al. (2015), Zolmitriptan inhibits neurogenic inflammation and pain during electrical stimulation in human skin; Eur. J. Pain, 19 966 4) Blackiston et al. (2017), Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity; Regenerative Med., 2 8 |
| Antibody Specification | |
| Alternate Names | BW 311C90 |
| Protein Specification | |
| Purity | >98% |