Probucol
Probucol
Probucol
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2679-1G | Probucol | 1g | $101.00 | |
| GBM-2679-10G | Probucol | 10g | $210.00 |
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Description
Blocks oxidation of cholesterol
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Specifications
Bioassays Specification Bio-Activity Blocks oxidation of cholesterol Chemical Name 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol Function / Pharmacology Unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions1. It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux2. It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage3. It attenuates NF-κB/NLRP3 signalling and augments Nrf-2-mediated antioxidant defense in nerve injury models4. Improves learning and memory in aging mice5. It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-16. CAS# 23288-49-5 MW 516.8 Molecular Formula C31H48O2S2 Solubility Soluble in DMSO (up to 100 mg/ml), in Ethanol (up to 50 mg/ml) Supplied powder Storage as supplied RT Ship temp Ambient References 1. A Yamamoto J. Atheroscler. Thromb. 2013 15:304 2. E Favari et al. Arterioscler. Thromb. Vasc. Biol. 2004 24:2345 3. N Moskal et al. PLoS Biol. 2023 21(3):e3001977 4. K Derangula et al. Int. Immunopharmacol. 2022 102:108397 5. Y Xie et al. Biomed. Pharmacother. 2021 144:112266 6. DB Santos et al. Mol. Neurobiol. 2020 57:3245 Antibody Specification Alternate Names DH-581 Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | Blocks oxidation of cholesterol |
| Chemical Name | 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol |
| Function / Pharmacology | Unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions1. It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux2. It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage3. It attenuates NF-κB/NLRP3 signalling and augments Nrf-2-mediated antioxidant defense in nerve injury models4. Improves learning and memory in aging mice5. It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-16. |
| CAS# | 23288-49-5 |
| MW | 516.8 |
| Molecular Formula | C31H48O2S2 |
| Solubility | Soluble in DMSO (up to 100 mg/ml), in Ethanol (up to 50 mg/ml) |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1. A Yamamoto J. Atheroscler. Thromb. 2013 15:304 2. E Favari et al. Arterioscler. Thromb. Vasc. Biol. 2004 24:2345 3. N Moskal et al. PLoS Biol. 2023 21(3):e3001977 4. K Derangula et al. Int. Immunopharmacol. 2022 102:108397 5. Y Xie et al. Biomed. Pharmacother. 2021 144:112266 6. DB Santos et al. Mol. Neurobiol. 2020 57:3245 |
| Antibody Specification | |
| Alternate Names | DH-581 |
| Protein Specification | |
| Purity | >98% |