Reserpine
Reserpine
Reserpine
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2689-1G | Reserpine | 1g | $105.00 |
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2689-1G | Reserpine | 1g | $105.00 |
| Bioassays Specification | |
| Bio-Activity | VMAT1/2 inhibitor (Irreversible) |
| Chemical Name | (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester |
| Function / Pharmacology | An indole alkaloid isolated from Rauwolfia serpentina which acts as a potent antihypertensive agent. Irreversibly inhibits both isoforms of vesicular monoamine transporter VMAT1 and 2, Ki=34 and 12 nM, respectively1,2. May be used to pharmacologically deplete monoamines in various animal models3. Inhibits the multidrug resistance protein P-glycoprotein, IC50=0.5 M3. Reserpine-induced hypokinesia is considered a useful animal model of Parkinson’s disease5. |
| CAS# | 50-55-5 |
| MW | 608.7 |
| Molecular Formula | C33H40N2O9 |
| Solubility | Soluble in DMSO (35 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. S Schuldiner et al. J. Biol. Chem. 1993 268:29 2. JD Erickson et al. Proc. Natl. Acad. Sci. USA 1996 93:5166 3. L Antkiewicz-Michaluk et al. Neurotox. Res. 2014 26:85 4. E Wang et al. Chem. Res. Toxicol. 2001 14:1596 5. S Duty and P Jenner Br. J. Pharmacol. 2011 164:1357 |
| Antibody Specification | |
| Alternate Names | NSC59272 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | VMAT1/2 inhibitor (Irreversible) |
| Chemical Name | (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester |
| Function / Pharmacology | An indole alkaloid isolated from Rauwolfia serpentina which acts as a potent antihypertensive agent. Irreversibly inhibits both isoforms of vesicular monoamine transporter VMAT1 and 2, Ki=34 and 12 nM, respectively1,2. May be used to pharmacologically deplete monoamines in various animal models3. Inhibits the multidrug resistance protein P-glycoprotein, IC50=0.5 M3. Reserpine-induced hypokinesia is considered a useful animal model of Parkinson’s disease5. |
| CAS# | 50-55-5 |
| MW | 608.7 |
| Molecular Formula | C33H40N2O9 |
| Solubility | Soluble in DMSO (35 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. S Schuldiner et al. J. Biol. Chem. 1993 268:29 2. JD Erickson et al. Proc. Natl. Acad. Sci. USA 1996 93:5166 3. L Antkiewicz-Michaluk et al. Neurotox. Res. 2014 26:85 4. E Wang et al. Chem. Res. Toxicol. 2001 14:1596 5. S Duty and P Jenner Br. J. Pharmacol. 2011 164:1357 |
| Antibody Specification | |
| Alternate Names | NSC59272 |
| Protein Specification | |
| Purity | >98% |