| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2959-10MG | Embelin | 10mg | $116.00 | |
| GBM-2959-50MG | Embelin | 50mg | $462.00 |
| Bioassays Specification | |
| Bio-Activity | XIAP inhibitor; Apoptosis inducer |
| Chemical Name | 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
| Function / Pharmacology | Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable. |
| CAS# | 550-24-3 |
| MW | 294.39 |
| Molecular Formula | C17H26O4 |
| Solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Modak et al. (2013), Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor; ACS Chem. Biol., 8 1311 2) Nikolovska-Coleska et al. (2004), Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database; J. Med. Chem., 47 2430 3) Shah et al. (2016), Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells; Pharmacol. Rep., 68 638 4) Chitra et al. (1994), Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.; Chemotherapy, 40 109 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | XIAP inhibitor; Apoptosis inducer |
| Chemical Name | 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
| Function / Pharmacology | Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable. |
| CAS# | 550-24-3 |
| MW | 294.39 |
| Molecular Formula | C17H26O4 |
| Solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 3 mg/ml with warming) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Modak et al. (2013), Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor; ACS Chem. Biol., 8 1311 2) Nikolovska-Coleska et al. (2004), Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database; J. Med. Chem., 47 2430 3) Shah et al. (2016), Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells; Pharmacol. Rep., 68 638 4) Chitra et al. (1994), Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.; Chemotherapy, 40 109 |
| Protein Specification | |
| Purity | >98% |
