| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-3474-100MG | Prochlorperazine maleate | 100mg | $116.00 | |
| GBM-3474-500MG | Prochlorperazine maleate | 500mg | $378.00 |
| Bioassays Specification | |
| Bio-Activity | Dopamine D2 Antagonist; Endocytosis inhibitor |
| Chemical Name | 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate |
| Function / Pharmacology | Inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2 A clinically useful antipsychotic agent3 with antimigraine4 and antiemetic activity5. |
| CAS# | 84-02-6 |
| MW | 606.1 |
| Molecular Formula | C20H24ClN3S • 2C4H4O4 |
| Solubility | Soluble in DMSO (up to 15 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Daniel et al. (2015), Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic, 16 635 2) Chew et al. (2020), Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell, 180 895 3) Hollister et al. (1969), Clinical use of psychotherapeutic drugs: current status; Clin. Pharmacol. Ther., 10 170 4) Cook and Newberry (2018), Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J., 40 148 5) Van den Berg et al. (1996), The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care, 24 538 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Dopamine D2 Antagonist; Endocytosis inhibitor |
| Chemical Name | 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate |
| Function / Pharmacology | Inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2 A clinically useful antipsychotic agent3 with antimigraine4 and antiemetic activity5. |
| CAS# | 84-02-6 |
| MW | 606.1 |
| Molecular Formula | C20H24ClN3S • 2C4H4O4 |
| Solubility | Soluble in DMSO (up to 15 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Daniel et al. (2015), Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic, 16 635 2) Chew et al. (2020), Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell, 180 895 3) Hollister et al. (1969), Clinical use of psychotherapeutic drugs: current status; Clin. Pharmacol. Ther., 10 170 4) Cook and Newberry (2018), Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J., 40 148 5) Van den Berg et al. (1996), The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care, 24 538 |
| Protein Specification | |
| Purity | >98% |
