| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-4644-20MG | Clemastine fumarate | 20mg | $74.00 | |
| GBM-4644-100MG | Clemastine fumarate | 100mg | $168.00 |
| Bioassays Specification | |
| Bio-Activity | Histamine H1 receptor antagonist |
| Chemical Name | (2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate |
| Function / Pharmacology | Histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role against neuroinflammation and demyelination via anti-inflammatory and anti-pyroptotic actions.2 Clemastine promoted oligodendrocyte differentiation in a rat model of spinal cord injury via muscarinic receptor mediated activation of ERK1/2 signaling.3 |
| CAS# | 14976-57-9 |
| MW | 459.96 |
| Molecular Formula | C21H26ClNO • C4H4O4 |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Li et al. (2015), Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination; Neurosci. Bull. 31 617 2) Motawi et al. (2023), Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model; Biochem. Pharmacol. 209 115435 3) Tong et al. (2022), Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury; Front. Pharmacol. 13 914153 |
| Antibody Specification | |
| Alternate Names | Tavist |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Histamine H1 receptor antagonist |
| Chemical Name | (2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate |
| Function / Pharmacology | Histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role against neuroinflammation and demyelination via anti-inflammatory and anti-pyroptotic actions.2 Clemastine promoted oligodendrocyte differentiation in a rat model of spinal cord injury via muscarinic receptor mediated activation of ERK1/2 signaling.3 |
| CAS# | 14976-57-9 |
| MW | 459.96 |
| Molecular Formula | C21H26ClNO • C4H4O4 |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Li et al. (2015), Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination; Neurosci. Bull. 31 617 2) Motawi et al. (2023), Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model; Biochem. Pharmacol. 209 115435 3) Tong et al. (2022), Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury; Front. Pharmacol. 13 914153 |
| Antibody Specification | |
| Alternate Names | Tavist |
| Protein Specification | |
| Purity | >98% |
