| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-5386-5MG | Z-Leu-Arg-AMC HCl | 5mg | $168.00 |
| Bioassays Specification | |
| Bio-Activity | Cathepsin K substrate |
| Chemical Name | CBZ-Leu-Arg-AMC, hydrochloride |
| Function / Pharmacology | Fluorogenic substrate1 for the following cathepsins (kcat/Km in M-1s-1): B (105)2, C/DPP-I (104)3, F (106)4, K/O2 (105)3, L (106)3, L2/V (105)5, O6, S (104)7, X/Z (104)8. The peptide is also cleaved by plasma kallikrein and kallikrein 89, and papain (kcat/Km=105 M-1s-1)3. Excitation: 365nm, Emission: 440nm. |
| CAS# | 156192-32-4 (Base) |
| MW | 615.1 |
| Molecular Formula | C30H38N6O6 • HCl |
| Solubility | Soluble in DMSO (20 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. FX Tavares et al. J. Med. Chem. 2004 47:588 2. C Therrien et al. Biochemistry 2001 40:2702 3. DK Nägler et al. Biochemistry 1999 38:4868 4. B Wang et al. J. Biol. Chem. 1998 273:32000 5. D Brömme et al. Biochemistry 1999 38:2377 6. G Velasco et al. J. Biol. Chem. 1994 269:27136 7. G Kopitar et al. Eur. J. Biochem. 1996 236:558 8. I Klemenčič et al. Eur. J. Biochem. 2000 267:5404 9. T Kishi et al. Biol. Chem. 2006 387:723 |
| Antibody Specification | |
| Alternate Names | Z-LR-AMC |
| Protein Specification | |
| Purity | >97% |
| Bioassays Specification | |
| Bio-Activity | Cathepsin K substrate |
| Chemical Name | CBZ-Leu-Arg-AMC, hydrochloride |
| Function / Pharmacology | Fluorogenic substrate1 for the following cathepsins (kcat/Km in M-1s-1): B (105)2, C/DPP-I (104)3, F (106)4, K/O2 (105)3, L (106)3, L2/V (105)5, O6, S (104)7, X/Z (104)8. The peptide is also cleaved by plasma kallikrein and kallikrein 89, and papain (kcat/Km=105 M-1s-1)3. Excitation: 365nm, Emission: 440nm. |
| CAS# | 156192-32-4 (Base) |
| MW | 615.1 |
| Molecular Formula | C30H38N6O6 • HCl |
| Solubility | Soluble in DMSO (20 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. FX Tavares et al. J. Med. Chem. 2004 47:588 2. C Therrien et al. Biochemistry 2001 40:2702 3. DK Nägler et al. Biochemistry 1999 38:4868 4. B Wang et al. J. Biol. Chem. 1998 273:32000 5. D Brömme et al. Biochemistry 1999 38:2377 6. G Velasco et al. J. Biol. Chem. 1994 269:27136 7. G Kopitar et al. Eur. J. Biochem. 1996 236:558 8. I Klemenčič et al. Eur. J. Biochem. 2000 267:5404 9. T Kishi et al. Biol. Chem. 2006 387:723 |
| Antibody Specification | |
| Alternate Names | Z-LR-AMC |
| Protein Specification | |
| Purity | >97% |
