| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-5406-5MG | PI-103 | 5mg | $126.00 | |
| GBM-5406-25MG | PI-103 | 25mg | $504.00 |
| Bioassays Specification | |
| Bio-Activity | PI3K, mTOR and DNA-PK inhibitor |
| Chemical Name | 3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol |
| Function / Pharmacology | A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110α, p110β, p110ɣ, p110δ, mTORC1, mTORC2 and DNA-PK respectively1,2. Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation3. Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines4. Induces autophagy in drug-resistant glioma5. Protects against -synuclein-induced toxicity in human neurons by induction of macroautophagy6. |
| CAS# | 371935-74-9 |
| MW | 348.4 |
| Molecular Formula | C19H16N4O3 |
| Solubility | Soluble in DMSO (40 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. ZA Knight et al. Cell 2006 125:733 2. FI Raynaud et al. Cancer Res. 2007 67:5840 3. Z Hong et al. Carcinogenesis 2011 32:1550 4. Z-Q Zou et al. Int. J. Mol. Med. 2009 24:97 5. Q-W Fan et al. Sci. Signal. 2010 3:ra81 6. M Hollerhage et al. Neuropharmacology 2019 149:13 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | PI3K, mTOR and DNA-PK inhibitor |
| Chemical Name | 3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol |
| Function / Pharmacology | A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110α, p110β, p110ɣ, p110δ, mTORC1, mTORC2 and DNA-PK respectively1,2. Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation3. Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines4. Induces autophagy in drug-resistant glioma5. Protects against -synuclein-induced toxicity in human neurons by induction of macroautophagy6. |
| CAS# | 371935-74-9 |
| MW | 348.4 |
| Molecular Formula | C19H16N4O3 |
| Solubility | Soluble in DMSO (40 mg/ml) |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. ZA Knight et al. Cell 2006 125:733 2. FI Raynaud et al. Cancer Res. 2007 67:5840 3. Z Hong et al. Carcinogenesis 2011 32:1550 4. Z-Q Zou et al. Int. J. Mol. Med. 2009 24:97 5. Q-W Fan et al. Sci. Signal. 2010 3:ra81 6. M Hollerhage et al. Neuropharmacology 2019 149:13 |
| Protein Specification | |
| Purity | >98% |
