ITT0077

ACE2

Polyclonal

-20°C/1 year

WB,ELISA

Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

1 mg/ml

Human,Mouse

Rabbit

The antiserum was produced against synthesized peptide derived from human ACE2. AA range:416-465

ACE2 Polyclonal Antibody detects endogenous levels of ACE2 protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

ACE2

Q9BYF1 Q8R0I0

ACE2; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15

angiotensin I converting enzyme 2(ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008],

Renin-angiotensin system,

Bile,Brain,Heart,Liver,Lung,Lymphoma,Testis,

extracellular region,extracellular space,cytoplasm,plasma membrane,cell surface,integral component of membrane,membrane raft,extracellular exosome,

cofactor:Binds 1 chloride ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat.,function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.,induction:Up-regulated in failing heart.,PTM:N-glycosylation on Asn-90 may limit SARS infectivity.,similarity:Belongs to the peptidase M2 family.,subunit:Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.,tissue specificity:Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.,

For Research Use Only! Not for diagnostic or therapeutic procedures.