menu
Your Cart

ITT0077 Immunotag™ ACE2 Polyclonal Antibody

ITT0077 Immunotag™ ACE2 Polyclonal Antibody
  • Gene/Protein: ACE2
  • Product Description: Immunotag™ ACE2 Polyclonal Antibody
280.0000
Price in reward points: 294

Available Options

Immunotag™ ACE2 Polyclonal Antibody
Antibody Specification
Datasheet

Target Protein

ACE2

Clonality

Polyclonal

Storage/Stability

-20°C/1 year

Application

WB,ELISA

Recommended Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Concentration

1 mg/ml

Reactive Species

Human,Mouse

Host Species

Rabbit

Immunogen

The antiserum was produced against synthesized peptide derived from human ACE2. AA range:416-465

Specificity

ACE2 Polyclonal Antibody detects endogenous levels of ACE2 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Gene Name

ACE2

Accession No.

Q9BYF1 Q8R0I0

Alternate Names

ACE2; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15

Description

angiotensin I converting enzyme 2(ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008],

Cell Pathway/ Category

Renin-angiotensin system,

Protein Expression

Bile,Brain,Heart,Liver,Lung,Lymphoma,Testis,

Subcellular Localization

extracellular region,extracellular space,cytoplasm,plasma membrane,cell surface,integral component of membrane,membrane raft,extracellular exosome,

Protein Function

cofactor:Binds 1 chloride ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat.,function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.,induction:Up-regulated in failing heart.,PTM:N-glycosylation on Asn-90 may limit SARS infectivity.,similarity:Belongs to the peptidase M2 family.,subunit:Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.,tissue specificity:Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.,

Usage

For Research Use Only! Not for diagnostic or therapeutic procedures.

Material Safety Data Sheet
English_US

Write a review

Note: HTML is not translated!
Bad Good
Captcha

CONNECT WITH US