| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1053-100MG | Mifepristone (RU486) | 100mg | $105.00 |
| Bioassays Specification | |
| Bio-Activity | Glucocorticoid antagonist |
| Chemical Name | 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one |
| Function / Pharmacology | Mifepristone is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3. |
| CAS# | 84371-65-3 |
| MW | 429.59 |
| Molecular Formula | C29H35NO2 |
| Solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses, Annu. Rev. Med. 48 129 / 2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins, J. Steroid Biochem. 31 161 / 3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor, Exp. Cell Res. 147 177 |
| Antibody Specification | |
| Alternate Names | RU486 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Glucocorticoid antagonist |
| Chemical Name | 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one |
| Function / Pharmacology | Mifepristone is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3. |
| CAS# | 84371-65-3 |
| MW | 429.59 |
| Molecular Formula | C29H35NO2 |
| Solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses, Annu. Rev. Med. 48 129 / 2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins, J. Steroid Biochem. 31 161 / 3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor, Exp. Cell Res. 147 177 |
| Antibody Specification | |
| Alternate Names | RU486 |
| Protein Specification | |
| Purity | >98% |
