| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1069-5MG | Mirin | 5mg | $105.00 | |
| GBM-1069-25MG | Mirin | 25mg | $294.00 |
| Bioassays Specification | |
| Bio-Activity | Mre11-Rad50-Nbs1 inhibitor |
| Chemical Name | 2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone |
| Function / Pharmacology | Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex which functions as a DNA damage sensor and activates ataxia-telangiectasia mutated kinase (ATM), a DNA repair enzyme1. Mirin blocks the 3’ and 5’ exonuclease activity of Mre112. It enhances the killing of glioblastoma cells after treatment with alkylating agents such as lomustine3. A very useful tool for determining the involvement of Mre11 in DNA damage response4,5. |
| CAS# | 1198097-97-0 |
| MW | 220.3 |
| Molecular Formula | C10H8N2O2S |
| Solubility | Soluble in DMSO (up to 30 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. A Dupré et al. Nat. Chem. Biol. 2008 4:119 2. A Shibata et al. Mol. Cell 2014 53:7 3. N Berte et al. Mol. Cancer Ther. 2016 15:2665 4. A Mayer et al. Cell Cycle 2016 15:546 5. MS Huh et al. Cell Death Dis. 2016 7:e220 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Mre11-Rad50-Nbs1 inhibitor |
| Chemical Name | 2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone |
| Function / Pharmacology | Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex which functions as a DNA damage sensor and activates ataxia-telangiectasia mutated kinase (ATM), a DNA repair enzyme1. Mirin blocks the 3’ and 5’ exonuclease activity of Mre112. It enhances the killing of glioblastoma cells after treatment with alkylating agents such as lomustine3. A very useful tool for determining the involvement of Mre11 in DNA damage response4,5. |
| CAS# | 1198097-97-0 |
| MW | 220.3 |
| Molecular Formula | C10H8N2O2S |
| Solubility | Soluble in DMSO (up to 30 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1. A Dupré et al. Nat. Chem. Biol. 2008 4:119 2. A Shibata et al. Mol. Cell 2014 53:7 3. N Berte et al. Mol. Cancer Ther. 2016 15:2665 4. A Mayer et al. Cell Cycle 2016 15:546 5. MS Huh et al. Cell Death Dis. 2016 7:e220 |
| Protein Specification | |
| Purity | >98% |
