| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1088-5MG | TCPOBOP | 5mg | $84.00 | |
| GBM-1088-25MG | TCPOBOP | 25mg | $252.00 |
| Bioassays Specification | |
| Bio-Activity | CAR agonist |
| Chemical Name | 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene |
| Function / Pharmacology | TCPOBOP is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis |
| CAS# | 76150-91-9 |
| MW | 402.06 |
| Molecular Formula | C16H8Cl4N2O2 |
| Solubility | Soluble in DMSO (up to 5 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951 / 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine. Carcinogenesis 13 1893 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | CAR agonist |
| Chemical Name | 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene |
| Function / Pharmacology | TCPOBOP is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis |
| CAS# | 76150-91-9 |
| MW | 402.06 |
| Molecular Formula | C16H8Cl4N2O2 |
| Solubility | Soluble in DMSO (up to 5 mg/ml). |
| Supplied | powder |
| Storage as supplied | RT |
| Ship temp | Ambient |
| References | 1) Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951 / 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine. Carcinogenesis 13 1893 |
| Protein Specification | |
| Purity | >98% |
