FCCP
FCCP
FCCP
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1182-10MG | FCCP | 10mg | $122.00 | |
| GBM-1182-50MG | FCCP | 50mg | $479.00 |
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Description
Mitochondrial oxidative phosphorylation inhibitor
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Specifications
Bioassays Specification Bio-Activity Mitochondrial oxidative phosphorylation inhibitor Chemical Name Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone Function / Pharmacology An extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic kidney 293 cells expressing either wild-type or “Swedish” mutant APP.3 An important tool for inhibiting mitochondrial membrane potential.2,4 Cell permeable. CAS# 370-86-5 MW 254.17 Molecular Formula C10H5F3N4O Solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Supplied powder Storage as supplied -20°C Ship temp Ambient References 1) Benz R & McLaughlin S, (1983). The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone). Biophys J 41 381 2) Gautier et al. (2000), A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells.; Neuroreport 11 2953 3) Connop et al. (1999), Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing; J. Neurochem. 72 1457 4) Collins et al. (2000), Inositol 1,4,5-trisphosphate-induced Ca2+ release in inhibited by mitochondrial depolarization.; Biochem. J. 347 593 Antibody Specification Alternate Names (4-(Trifluoromethoxy)phenyl)carbonohydrazonoyl dicyanide Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | Mitochondrial oxidative phosphorylation inhibitor |
| Chemical Name | Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone |
| Function / Pharmacology | An extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic kidney 293 cells expressing either wild-type or “Swedish” mutant APP.3 An important tool for inhibiting mitochondrial membrane potential.2,4 Cell permeable. |
| CAS# | 370-86-5 |
| MW | 254.17 |
| Molecular Formula | C10H5F3N4O |
| Solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Benz R & McLaughlin S, (1983). The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone). Biophys J 41 381 2) Gautier et al. (2000), A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells.; Neuroreport 11 2953 3) Connop et al. (1999), Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing; J. Neurochem. 72 1457 4) Collins et al. (2000), Inositol 1,4,5-trisphosphate-induced Ca2+ release in inhibited by mitochondrial depolarization.; Biochem. J. 347 593 |
| Antibody Specification | |
| Alternate Names | (4-(Trifluoromethoxy)phenyl)carbonohydrazonoyl dicyanide |
| Protein Specification | |
| Purity | >98% |