| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1359-5MG | SMI-4a | 5mg | $105.00 | |
| GBM-1359-25MG | SMI-4a | 25mg | $357.00 |
| Bioassays Specification | |
| Bio-Activity | PIM1 inhibitor |
| Chemical Name | 5-(3-Trifluoromethylbenzylidene)thiazolidine |
| Function / Pharmacology | A selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases1. Induces cell cycle arrest in leukemia and prostate cancer cells2. Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive3. A useful tool for exploring the involvement of Pim in cellular signaling4. Cell permeable. |
| CAS# | 438190-29-5 |
| MW | 273.23 |
| Molecular Formula | C11H6F3NO2S |
| Solubility | Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Xia et al. (2009), Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases; J. Med. Chem., 52 74 2) Beharry et al. (2009), Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells; Mol. Cancer Ther., 8 1473 3) Lin et al. (2010), A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma; Blood, 115 824 4) Zhang et al. (2009), PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells; Cancer Biol. Ther., 8 846 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | PIM1 inhibitor |
| Chemical Name | 5-(3-Trifluoromethylbenzylidene)thiazolidine |
| Function / Pharmacology | A selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases1. Induces cell cycle arrest in leukemia and prostate cancer cells2. Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive3. A useful tool for exploring the involvement of Pim in cellular signaling4. Cell permeable. |
| CAS# | 438190-29-5 |
| MW | 273.23 |
| Molecular Formula | C11H6F3NO2S |
| Solubility | Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Xia et al. (2009), Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases; J. Med. Chem., 52 74 2) Beharry et al. (2009), Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells; Mol. Cancer Ther., 8 1473 3) Lin et al. (2010), A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma; Blood, 115 824 4) Zhang et al. (2009), PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells; Cancer Biol. Ther., 8 846 |
| Protein Specification | |
| Purity | >98% |
