| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-1456-5MG | Optovin | 5mg | $147.00 | |
| GBM-1456-25MG | Optovin | 25mg | $588.00 |
| Bioassays Specification | |
| Bio-Activity | TRPA1 channel activator |
| Chemical Name | 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone |
| Function / Pharmacology | Reversible, photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo. Photodetection is performed by sensory neurons expressing the TRPA1 cation channel which is activated via structure-dependent photochemical reactions with redox-sensitive cysteine residues.1 |
| CAS# | 348575-88-2 |
| MW | 315.41 |
| Molecular Formula | C15H13N3OS2 |
| Solubility | Soluble in DMSO (up to 30 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Kokel et al. (2013), Photochemical activation of TRPA1 channels in neurons and animals; Nat. Chem. Biol., 9 257 |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | TRPA1 channel activator |
| Chemical Name | 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone |
| Function / Pharmacology | Reversible, photoactive TRPA1 activator. Optovin stimulates human TRPA1 channels and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM) and mice, in vivo. Photodetection is performed by sensory neurons expressing the TRPA1 cation channel which is activated via structure-dependent photochemical reactions with redox-sensitive cysteine residues.1 |
| CAS# | 348575-88-2 |
| MW | 315.41 |
| Molecular Formula | C15H13N3OS2 |
| Solubility | Soluble in DMSO (up to 30 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Kokel et al. (2013), Photochemical activation of TRPA1 channels in neurons and animals; Nat. Chem. Biol., 9 257 |
| Protein Specification | |
| Purity | >98% |
