| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2085-1MG | Mithramycin A | 1mg | $89.00 | |
| GBM-2085-5MG | Mithramycin A | 5mg | $347.00 |
| Bioassays Specification | |
| Bio-Activity | Transcription inhibitor; Inhibits DNA methyltransferase |
| Function / Pharmacology | Inhibits DNA methyl transferase1. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibitings their expression2. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis3. |
| CAS# | 18378-89-7 |
| MW | 1085.15 |
| Molecular Formula | C52H76O24 |
| Solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Lin et al. (2007), Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells; Anticancer Drugs, 18 1157 2) Jia et al. (2010), Combined treatment of pancreatic cancer cells with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic anti-tumor activity; Cancer Res., 70 1111 3) Lee et al. (2006), Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites; Mol. Cancer Ther., 5 2737 |
| Antibody Specification | |
| Alternate Names | A2371; Antibiotic LA 7017; Aureolic Acid; NSC 24559; PA 144; Plicamycin |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Transcription inhibitor; Inhibits DNA methyltransferase |
| Function / Pharmacology | Inhibits DNA methyl transferase1. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibitings their expression2. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis3. |
| CAS# | 18378-89-7 |
| MW | 1085.15 |
| Molecular Formula | C52H76O24 |
| Solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Lin et al. (2007), Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells; Anticancer Drugs, 18 1157 2) Jia et al. (2010), Combined treatment of pancreatic cancer cells with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic anti-tumor activity; Cancer Res., 70 1111 3) Lee et al. (2006), Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites; Mol. Cancer Ther., 5 2737 |
| Antibody Specification | |
| Alternate Names | A2371; Antibiotic LA 7017; Aureolic Acid; NSC 24559; PA 144; Plicamycin |
| Protein Specification | |
| Purity | >98% |
