Prostratin
Prostratin
Prostratin
| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2169-1MG | Prostratin | 1mg | $231.00 | |
| GBM-2169-5MG | Prostratin | 5mg | $1,050.00 |
-
Description
PKC activator; Promotes neuro-regeneration
-
Specifications
Bioassays Specification Bio-Activity PKC activator; Promotes neuro-regeneration Chemical Name 13-O-Acetyl-12-deoxyphorbol Function / Pharmacology A terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrate.1,2 Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents.3 Induces reactivation of latent HIV.4 Exerts a proliferative effect on neural progenitor cells in vitro and in vivo.5 CAS# 60857-08-1 MW 390.47 Molecular Formula C22H30O6 Solubility Soluble in DMSO (up to 30 mg/ml). Supplied wax Storage as supplied -20°C Ship temp Ambient References 1) Cashmore et al. (1976), The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata; Tetrahedron Lett., 17 1737 2) Miana et al. (2015), Prostratin: An Overview; Mini Rev. Med. Chem., 15 1122 3) Shen et al. (2015), The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents; Cancer Lett., 356 (2 Pt. B) 686 4) Biancotto et al. (2004), Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue; J. Virol., 78 10507 5) Geribaldi-Doldan et al. (2015), 12-dePKC activation ; Int. J, Neuropsychopharmacol., 19 pyv085 Antibody Specification Alternate Names 12-Deoxyphorbol 13-Acetate; dPAc Protein Specification Purity >98% - Reviews
| Bioassays Specification | |
| Bio-Activity | PKC activator; Promotes neuro-regeneration |
| Chemical Name | 13-O-Acetyl-12-deoxyphorbol |
| Function / Pharmacology | A terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrate.1,2 Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents.3 Induces reactivation of latent HIV.4 Exerts a proliferative effect on neural progenitor cells in vitro and in vivo.5 |
| CAS# | 60857-08-1 |
| MW | 390.47 |
| Molecular Formula | C22H30O6 |
| Solubility | Soluble in DMSO (up to 30 mg/ml). |
| Supplied | wax |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Cashmore et al. (1976), The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata; Tetrahedron Lett., 17 1737 2) Miana et al. (2015), Prostratin: An Overview; Mini Rev. Med. Chem., 15 1122 3) Shen et al. (2015), The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents; Cancer Lett., 356 (2 Pt. B) 686 4) Biancotto et al. (2004), Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue; J. Virol., 78 10507 5) Geribaldi-Doldan et al. (2015), 12-dePKC activation ; Int. J, Neuropsychopharmacol., 19 pyv085 |
| Antibody Specification | |
| Alternate Names | 12-Deoxyphorbol 13-Acetate; dPAc |
| Protein Specification | |
| Purity | >98% |