| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2430-1G | Amphotericin B | 1g | $126.00 | |
| GBM-2430-5G | Amphotericin B | 5g | $504.00 |
| Bioassays Specification | |
| Bio-Activity | Antifungal agent |
| Function / Pharmacology | Amphotericin B is a powerful antimycotic, effective against a wide variety of fungi, including yeast, via two mechanisms: forming pores in the plasma membrane, leading to leakage and death1, and causing oxidative stress2. Other mechanisms have more recently been proposed, including formation of intracellular amphotericin B-containing vesicular bodies that target vacuoles3. Amphotericin B is also effective against some parasites, such as Leishmania spp4. Because of its potency and broad-spectrum activity, it is a common additive used to maintain sterility in cell culture and viral transport media. |
| CAS# | 1397-89-3 |
| MW | 924.1 |
| Molecular Formula | C47H73NO17 |
| Solubility | Soluble in DMSO (up to 18 mg/ml), |
| Supplied | powder |
| Storage as supplied | -20°C / protect from light |
| Ship temp | Ambient |
| References | 1. SC Kinsky Annu. Rev. Pharmacol. 1970 10:119 2. ML Sokol-Anderson et al. J. Infect. Dis. 1986 154:76 3. E Grela et al. Sci. Rep. 2019 9:17029 4. YD Paila et al. Biochem. Biophys. Res. Commun. 2010 399:429 |
| Antibody Specification | |
| Alternate Names | NSC 527017 |
| Protein Specification | |
| Purity | >90% |
| Bioassays Specification | |
| Bio-Activity | Antifungal agent |
| Function / Pharmacology | Amphotericin B is a powerful antimycotic, effective against a wide variety of fungi, including yeast, via two mechanisms: forming pores in the plasma membrane, leading to leakage and death1, and causing oxidative stress2. Other mechanisms have more recently been proposed, including formation of intracellular amphotericin B-containing vesicular bodies that target vacuoles3. Amphotericin B is also effective against some parasites, such as Leishmania spp4. Because of its potency and broad-spectrum activity, it is a common additive used to maintain sterility in cell culture and viral transport media. |
| CAS# | 1397-89-3 |
| MW | 924.1 |
| Molecular Formula | C47H73NO17 |
| Solubility | Soluble in DMSO (up to 18 mg/ml), |
| Supplied | powder |
| Storage as supplied | -20°C / protect from light |
| Ship temp | Ambient |
| References | 1. SC Kinsky Annu. Rev. Pharmacol. 1970 10:119 2. ML Sokol-Anderson et al. J. Infect. Dis. 1986 154:76 3. E Grela et al. Sci. Rep. 2019 9:17029 4. YD Paila et al. Biochem. Biophys. Res. Commun. 2010 399:429 |
| Antibody Specification | |
| Alternate Names | NSC 527017 |
| Protein Specification | |
| Purity | >90% |
