| Catalog | Description | Size | Price (USD) | Qty |
|---|---|---|---|---|
| GBM-2570-5MG | Vincristine sulfate | 5mg | $63.00 | |
| GBM-2570-25MG | Vincristine sulfate | 25mg | $252.00 |
| Bioassays Specification | |
| Bio-Activity | Microtubule depolymerizer |
| Chemical Name | 22-Oxovincaleukoblastine sulfate |
| Function / Pharmacology | Arrests cell cycle at G2/M by interfering with mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins1,2. Induces apoptosis3. Clinically useful cancer chemotherapeutic agent. |
| CAS# | 2068-78-2 |
| MW | 923.06 |
| Molecular Formula | C46H56N4O10 |
| Solubility | Soluble in Water (up to 80 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Jordan et al. (1998), Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle; Med. Res. Rev., 18 259 2) Lobert et al. (1996), Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine; Biochemistry, 35 6806 3) Wang et al. (1999), The effect of antimicrotubilt agents on signal transduction pathways of apoptosis: a review: Cancer Chemother. Pharmacol., 44 355 |
| Antibody Specification | |
| Alternate Names | Leurocristine sulfate |
| Protein Specification | |
| Purity | >98% |
| Bioassays Specification | |
| Bio-Activity | Microtubule depolymerizer |
| Chemical Name | 22-Oxovincaleukoblastine sulfate |
| Function / Pharmacology | Arrests cell cycle at G2/M by interfering with mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins1,2. Induces apoptosis3. Clinically useful cancer chemotherapeutic agent. |
| CAS# | 2068-78-2 |
| MW | 923.06 |
| Molecular Formula | C46H56N4O10 |
| Solubility | Soluble in Water (up to 80 mg/ml). |
| Supplied | powder |
| Storage as supplied | -20°C |
| Ship temp | Ambient |
| References | 1) Jordan et al. (1998), Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle; Med. Res. Rev., 18 259 2) Lobert et al. (1996), Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine; Biochemistry, 35 6806 3) Wang et al. (1999), The effect of antimicrotubilt agents on signal transduction pathways of apoptosis: a review: Cancer Chemother. Pharmacol., 44 355 |
| Antibody Specification | |
| Alternate Names | Leurocristine sulfate |
| Protein Specification | |
| Purity | >98% |
