ITA0214
ITA0214
ITA0214
from
$526.00
Price in reward points: 526
- Catalog: ITA0214
- Gene/Protein: SENP6
- Product Description: Immunotag™ SENP6 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein SENP6 Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC,ELISA Recommended Dilution IHC 1:50-1:200 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen A synthesized peptide derived from human SENP6 Specificity SENP6 Antibody detects endogenous levels of SENP6 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name SENP6 Accession No. Q9GZR1 Alternate Names 2810017C20Rik; FLJ11355; FLJ11887; KIAA0389; KIAA0797; SENP 6; Senp6; SENP6_HUMAN; Sentrin specific protease 6; Sentrin-specific protease 6; Sentrin/SUMO specific protease SENP6; Sentrin/SUMO-specific protease SENP6; SSP 1; SSP1; SUMO 1 specific protease 1; SUMO 1 specific protease; SUMO-1-specific protease 1; SUMO1 specific protease 1; SUMO1 specific protease; SUMO1/sentrin specific peptidase 6; SUSP 1; SUSP1; Description Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 126kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
|
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | SENP6 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC,ELISA |
| Recommended Dilution | IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human SENP6 |
| Specificity | SENP6 Antibody detects endogenous levels of SENP6 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | SENP6 |
| Accession No. | Q9GZR1 |
| Alternate Names | 2810017C20Rik; FLJ11355; FLJ11887; KIAA0389; KIAA0797; SENP 6; Senp6; SENP6_HUMAN; Sentrin specific protease 6; Sentrin-specific protease 6; Sentrin/SUMO specific protease SENP6; Sentrin/SUMO-specific protease SENP6; SSP 1; SSP1; SUMO 1 specific protease 1; SUMO 1 specific protease; SUMO-1-specific protease 1; SUMO1 specific protease 1; SUMO1 specific protease; SUMO1/sentrin specific peptidase 6; SUSP 1; SUSP1; |
| Description | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 126kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |