ITA0288
ITA0288
- Catalog: ITA0288
- Gene/Protein: PTTG1
- Product Description: Immunotag™ PTTG1 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | PTTG1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IF/ICC,ELISA |
Recommended Dilution | WB: 1:500~1:3000 IF/ICC: 1:100~1:500 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human PTTG1 |
Specificity | PTTG1 antibody detects endogenous levels of total PTTG1 |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | PTTG1 |
Accession No. | O95997 |
Alternate Names | AW555095; C87862; Cut2; EAP 1; EAP1; ESP1 associated protein 1; Esp1-associated protein; hPTTG; MGC126883; MGC138276; Pds1; Pituitary tumor transforming 1; Pituitary tumor transforming protein 1; Pituitary tumor-transforming 1, isoform CRA_a; Pituitary tumor-transforming 1, isoform CRA_b; Pituitary tumor-transforming gene 1; Pituitary tumor-transforming gene 1 protein; PTTG 1; PTTG; PTTG1; PTTG1 protein; PTTG1_HUMAN; Pttg3; Securin; Tumor transforming 1; Tumor transforming protein 1; Tumor-transforming protein 1; TUTR 1; TUTR1; |
Description | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 30kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |