ITA0433
ITA0433
ITA0433
from
$526.00
Price in reward points: 526
- Catalog: ITA0433
- Gene/Protein: DMPK
- Product Description: Immunotag™ DMPK Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein DMPK Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IF/ICC,ELISA Recommended Dilution WB 1:500-1:2000, IF/ICC 1:100-1:500 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen A synthesized peptide derived from human DMPK Specificity DMPK Antibody detects endogenous levels of DMPK Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name DMPK Accession No. Q09013 Alternate Names DM 1; DM; DM kinase; DM protein kinase; DM-kinase; DM1; DM1 protein kinase; DM1PK; DMK; DMPK; DMPK_HUMAN; Dystrophia myotonica 1; Dystrophia myotonica protein kinase; MDPK; MT PK; MT-PK; Myotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; Myotonin protein kinase A; Myotonin protein kinase; Myotonin-protein kinase; Thymopoietin homolog; Description Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 70kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
|
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | DMPK |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500-1:2000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human DMPK |
| Specificity | DMPK Antibody detects endogenous levels of DMPK |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | DMPK |
| Accession No. | Q09013 |
| Alternate Names | DM 1; DM; DM kinase; DM protein kinase; DM-kinase; DM1; DM1 protein kinase; DM1PK; DMK; DMPK; DMPK_HUMAN; Dystrophia myotonica 1; Dystrophia myotonica protein kinase; MDPK; MT PK; MT-PK; Myotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; Myotonin protein kinase A; Myotonin protein kinase; Myotonin-protein kinase; Thymopoietin homolog; |
| Description | Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 70kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |