ITA1309
ITA1309
- Catalog: ITA1309
- Gene/Protein: BAG1
- Product Description: Immunotag™ Bag 1 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | Bag 1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human Bag 1 |
| Specificity | Bag 1 Antibody detects endogenous levels of total Bag 1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | BAG1 |
| Accession No. | Q99933 |
| Alternate Names | Bag 1; BAG family molecular chaperone regulator 1; BAG-1; BAG1; BAG1_HUMAN; BCL 2 Associated Athanogene 1; BCL 2 associated athanogene; BCL 2 binding athanogene 1; Bcl-2-associated athanogene 1; BCL2 associated athanogene 1; BCL2 associated athanogene; Glucocorticoid receptor-associated protein RAP46; HAP1; Haptoglobin; RAP 46; RAP46; |
| Description | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 31 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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