ITA1373
ITA1373
- Catalog: ITA1373
- Gene/Protein: ITGA5
- Product Description: Immunotag™ Integrin α5 (CD49e) Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | Integrin α5 (CD49e) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500-1:2000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human Integrin α5 (CD49e) |
| Specificity | Integrin α5 (CD49e) Antibody detects endogenous levels of total Integrin α5 (CD49e) |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | ITGA5 |
| Accession No. | P08648 |
| Alternate Names | CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; Fibronectin receptor, alpha subunit; FNRA; Integrin alpha 5 (fibronectin receptor alpha); Integrin alpha-5; Integrin alpha-5 light chain; Integrin alpha-F; Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5_HUMAN; Itga5; Very late activation protein 5, alpha subunit; VLA-5; VLA5; VLA5A; |
| Description | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 114 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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