ITA1419
ITA1419
- Catalog: ITA1419
- Gene/Protein: EPHB2
- Product Description: Immunotag™ EPHB2 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | EPHB2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500-1:2000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human EPHB2 |
| Specificity | EPHB2 Antibody detects endogenous levels of total EPHB2 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | EPHB2 |
| Accession No. | P29323 |
| Alternate Names | cek5; Developmentally regulated EPH related tyrosine kinase; DRT; EK5; ELK related protein tyrosine kinase; Eph receptor B2; EPH tyrosine kinase 3; EPH-like kinase 5; EPHB2; EPHB2_HUMAN; Ephrin type B receptor 2; Ephrin type-B receptor 2; EPHT 3; ERK; ETECK; hEK5; Nuk; Prkm 5; Receptor protein tyrosine kinase HEK 5; Renal carcinoma antigen NY-REN-47; Sek 3; Tyro 5; Tyrosine protein kinase receptor CEK 5; Tyrosine protein kinase receptor EPH 3; Tyrosine protein kinase receptor QEK 5; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase TYRO5; |
| Description | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 117 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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