ITA1466
ITA1466
ITA1466
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- Catalog: ITA1466
- Gene/Protein: ADAM10
- Product Description: Immunotag™ ADAM10 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein ADAM10 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IF/ICC,ELISA Recommended Dilution WB 1:500-1:2000, IF/ICC 1:100-1:500 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen A synthesized peptide derived from human ADAM10 Specificity ADAM10 Antibody detects endogenous levels of total ADAM10 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name ADAM10 Accession No. O14672 Alternate Names A disintegrin and metalloprotease domain 10; A disintegrin and metalloproteinase domain 10; AD 10; AD10; AD18; ADA10_HUMAN; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; CD 156c; CD156c; CD156c antigen; CDw156; disintegrin and metalloproteinase domain containing protein 10; Disintegrin and metalloproteinase domain-containing protein 10; HsT 18717; HsT18717; Kuz; Kuzbanian; Kuzbanian protein homolog; Kuzbanian, Drosophila, homolog of; MADM; Mammalian disintegrin metalloprotease; Mammalian disintegrin-metalloprotease; RAK; Description Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 84 kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
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| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | ADAM10 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500-1:2000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human ADAM10 |
| Specificity | ADAM10 Antibody detects endogenous levels of total ADAM10 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | ADAM10 |
| Accession No. | O14672 |
| Alternate Names | A disintegrin and metalloprotease domain 10; A disintegrin and metalloproteinase domain 10; AD 10; AD10; AD18; ADA10_HUMAN; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; CD 156c; CD156c; CD156c antigen; CDw156; disintegrin and metalloproteinase domain containing protein 10; Disintegrin and metalloproteinase domain-containing protein 10; HsT 18717; HsT18717; Kuz; Kuzbanian; Kuzbanian protein homolog; Kuzbanian, Drosophila, homolog of; MADM; Mammalian disintegrin metalloprotease; Mammalian disintegrin-metalloprotease; RAK; |
| Description | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 84 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |