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ITA1601

ITA1601-1
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ITA1601-1
ITA1601-2
ITA1601
  • Catalog: ITA1601
  • Gene/Protein: CCND2
  • Product Description: Immunotag™ Cyclin D2 (Phospho-Thr280) Antibody
385.0000
Price in reward points: 385

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Immunotag™ Cyclin D2 (Phospho-Thr280) Antibody
Antibody Specification
Datasheet

Target Protein Cyclin D2 (Phospho-Thr280)
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IF/ICC,ELISA
Recommended Dilution WB 1:500-1:2000, IF/ICC 1:100-1:500
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide derived from human Cyclin D2 (Phospho-Thr280)
Specificity Cyclin D2 (Phospho-Thr280) Antibody detects endogenous levels of total Cyclin D2 (Phospho-Thr280)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name CCND2
Accession No. P30279
Alternate Names CCND 2; ccnd2; CCND2_HUMAN; CyclinD2; G1/S specific cyclin D2; G1/S-specific cyclin-D2; KIAK0002; MGC102758; MPPH3;
Description Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 33 kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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