ITA2158
ITA2158
- Catalog: ITA2158
- Gene/Protein: CDC42BPB
- Product Description: Immunotag™ MRCKbeta Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | MRCKbeta |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,IF/ICC,ELISA |
| Recommended Dilution | WB 1:1000 IHC 1:200, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human MRCKbeta |
| Specificity | MRCKbeta Antibody detects endogenous levels of total MRCKbeta |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | CDC42BPB |
| Accession No. | Q9Y5S2 |
| Alternate Names | CDC42 binding protein kinase beta; CDC42-binding protein kinase beta; CDC42BPB; DMPK like beta; DMPK-like beta; KIAA1124; MRCK beta; MRCKB_HUMAN; Myotonic dystrophy kinase related CDC42 binding kinase beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Myotonic dystrophy protein kinase like beta; Myotonic dystrophy protein kinase-like beta; Serine/threonine protein kinase MRCK beta; Serine/threonine-protein kinase MRCK beta; |
| Description | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 194kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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