ITA2314
ITA2314
- Catalog: ITA2314
- Gene/Protein: MAGEA2; MAGEA2B
- Product Description: Immunotag™ MAGA2 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | MAGA2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:1000-3000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human MAGA2 |
| Specificity | MAGA2 Antibody detects endogenous levels of total MAGA2 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | MAGEA2; MAGEA2B |
| Accession No. | P43356 |
| Alternate Names | Cancer/testis antigen 1.2; Cancer/testis antigen family 1, member 2; CT1.2; MAGE 2; MAGE 2 antigen; MAGE2; MAGEA 2; MAGEA2; MAGEA2A; MAGEA2B; Melanoma antigen 2; Melanoma antigen family A, 2; Melanoma antigen family A, 2B; Melanoma antigen, family A, 2, copy b; Melanoma associated antigen 2; |
| Description | Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 35 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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