ITA2773
ITA2773
- Catalog: ITA2773
- Gene/Protein: LONP1
- Product Description: Immunotag™ LONP1 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | LONP1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC |
| Recommended Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human LONP1. |
| Specificity | LONP1 antibody detects endogenous levels of LONP1. |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | LONP1 |
| Accession No. | P36776 |
| Alternate Names | hLON; hLON ATP dependent protease; LON; lon peptidase 1, mitochondrial; LON protease; Lon protease homolog; Lon protease like protein; Lon protease-like protein; LONHs; LONM_HUMAN; LONP; Lonp1; MGC1498; mitochondrial; Mitochondrial ATP dependent protease Lon; Mitochondrial ATP-dependent protease Lon; Mitochondrial lon peptidase 1; PIM1; Protease serine 15; PRSS15; Serine protease 15; |
| Description | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 100 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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