ITA3001
ITA3001
- Catalog: ITA3001
- Gene/Protein: AP2A1
- Product Description: Immunotag™ alpha Adaptin Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | alpha Adaptin |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC |
| Recommended Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human alpha Adaptin. |
| Specificity | alpha Adaptin antibody detects endogenous levels of alpha Adaptin. |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | AP2A1 |
| Accession No. | O95782 |
| Alternate Names | 100 kDa coated vesicle protein A; Adapter-related protein complex 2 alpha-1 subunit; adapter-related protein complex 2 subunit alpha-1; Adaptin alpha A; Adaptin alpha; Adaptor protein complex AP 2 alpha 1 subunit; adaptor protein complex AP 2 subunit alpha 1; Adaptor protein complex AP-2 subunit alpha-1; Adaptor protein complex AP2 alpha 1 subunit; adaptor protein complex AP2 subunit alpha 1; Adaptor related protein complex 2 alpha 1 subunit; Adaptor related protein complex AP 2 alpha 1 subunit; Adaptor related protein complex AP2 alpha 1 subunit; ADTAA; Alpha A adaptin; Alpha adaptin A; Alpha-adaptin A; alpha1 adaptin; Alpha1-adaptin; AP 2 alpha; AP 2 complex subunit alpha 1; AP-2 complex subunit alpha-1; AP2 complex subunit alpha 1; AP2-ALPHA; Ap2a1; AP2A1_HUMAN; CLAPA 1; CLAPA1; Clathrin adaptor complex AP2. alpha subunit; Clathrin assembly protein complex 2 alpha A large chain; Clathrin assembly protein complex 2 alpha-A large chain; Clathrin associated / assembly / adaptor protein large alpha 1; clathrin associated assembly adaptor protein large alpha 1; clathrin associated/assembly/adaptor protein, large, alpha 1; Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit; |
| Description | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 108 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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