ITA3019
ITA3019
ITA3019
from
$526.00
Price in reward points: 526
- Catalog: ITA3019
- Gene/Protein: SH3KBP1
- Product Description: Immunotag™ CIN85 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein CIN85 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC Recommended Dilution WB 1:500-1:2000, IHC 1:50-1:200 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen A synthesized peptide derived from human CIN85. Specificity CIN85 antibody detects endogenous levels of CIN85. Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name SH3KBP1 Accession No. Q96B97 Alternate Names c Cbl interacting protein; Cbl interacting protein; Cbl interacting protein of 85 kDa; Cbl-interacting protein of 85 kDa; CD2 binding protein 3; CD2-binding protein 3; CD2BP3; CIN 85; CIN85; GIG 10; GIG10; HSB 1; HSB-1; HSB1; Human Src family kinase binding protein 1; Human Src family kinase-binding protein 1; MIG 18; MIG18; Migration inducing gene 18; Migration inducing gene 18 protein; SH3 domain kinase binding protein 1; SH3 domain-containing kinase-binding protein 1; SH3BP 1; SH3K1_HUMAN; SH3KBP1; Src family kinase binding protein 1; src related kinase binding protein 1; Description Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 85 kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
|
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | CIN85 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC |
| Recommended Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human CIN85. |
| Specificity | CIN85 antibody detects endogenous levels of CIN85. |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | SH3KBP1 |
| Accession No. | Q96B97 |
| Alternate Names | c Cbl interacting protein; Cbl interacting protein; Cbl interacting protein of 85 kDa; Cbl-interacting protein of 85 kDa; CD2 binding protein 3; CD2-binding protein 3; CD2BP3; CIN 85; CIN85; GIG 10; GIG10; HSB 1; HSB-1; HSB1; Human Src family kinase binding protein 1; Human Src family kinase-binding protein 1; MIG 18; MIG18; Migration inducing gene 18; Migration inducing gene 18 protein; SH3 domain kinase binding protein 1; SH3 domain-containing kinase-binding protein 1; SH3BP 1; SH3K1_HUMAN; SH3KBP1; Src family kinase binding protein 1; src related kinase binding protein 1; |
| Description | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 85 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |