ITA3037
ITA3037
- Catalog: ITA3037
- Gene/Protein: DIS3
- Product Description: Immunotag™ DIS3 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | DIS3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC |
| Recommended Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human DIS3. |
| Specificity | DIS3 antibody detects endogenous levels of DIS3. |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | DIS3 |
| Accession No. | Q9Y2L1 |
| Alternate Names | 2810028N01Rik; bA555G22; Dis3; DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog (S. cerevisiae); DIS3 mitotic control homolog; DIS3 mitotic control, S. cerevisiae, homolog of; dis3p; EXOSC11; Exosome complex exonuclease RRP44; exosome component 11; KIAA1008; Mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal RNA processing protein 44; Ribosomal RNA processing protein 44, S. cerevisiae, homolog of; Ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44; RRP44_HUMAN; |
| Description | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 110 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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