ITA3066
ITA3066
- Catalog: ITA3066
- Gene/Protein: INSIG1
- Product Description: Immunotag™ INSIG1 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | INSIG1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC |
| Recommended Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human INSIG1. |
| Specificity | INSIG1 antibody detects endogenous levels of INSIG1. |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | INSIG1 |
| Accession No. | O15503 |
| Alternate Names | CL 6; CL6; INSI1_HUMAN; INSIG 1; INSIG 1 membrane protein; INSIG-1; insig1; INSIG1 membrane protein; Insulin induced gene 1; Insulin induced gene 1 protein; Insulin-induced gene 1 protein; MGC1405; |
| Description | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 28-31; 66-70 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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