ITA3347
ITA3347
- Catalog: ITA3347
- Gene/Protein: NR5A1
- Product Description: Immunotag™ NR5A1 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | NR5A1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-1:2000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide |
| Specificity | NR5A1 antibody detects endogenous levels of total NR5A1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Gene Name | NR5A1 |
| Accession No. | Q13285 |
| Alternate Names | AD4BP; Adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ 1; FTZ1; FTZF 1; FTZF1; Fushi tarazu factor (Drosophila) homolog 1; Fushi tarazu factor homolog 1; hSF 1; NR5A1; Nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; POF7; SF 1; SF-1; SF1; SPGF8; SRXY3; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; Steroidogenic factor 1 nuclear receptor; STF 1; STF-1; STF1; STF1_HUMAN; |
| Description | Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 55 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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