ITA3347
ITA3347
ITA3347
from
$526.00
Price in reward points: 526
- Catalog: ITA3347
- Gene/Protein: NR5A1
- Product Description: Immunotag™ NR5A1 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein NR5A1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-1:2000 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen A synthesized peptide Specificity NR5A1 antibody detects endogenous levels of total NR5A1 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Gene Name NR5A1 Accession No. Q13285 Alternate Names AD4BP; Adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ 1; FTZ1; FTZF 1; FTZF1; Fushi tarazu factor (Drosophila) homolog 1; Fushi tarazu factor homolog 1; hSF 1; NR5A1; Nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; POF7; SF 1; SF-1; SF1; SPGF8; SRXY3; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; Steroidogenic factor 1 nuclear receptor; STF 1; STF-1; STF1; STF1_HUMAN; Description Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 55 kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
|
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | NR5A1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-1:2000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide |
| Specificity | NR5A1 antibody detects endogenous levels of total NR5A1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Gene Name | NR5A1 |
| Accession No. | Q13285 |
| Alternate Names | AD4BP; Adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ 1; FTZ1; FTZF 1; FTZF1; Fushi tarazu factor (Drosophila) homolog 1; Fushi tarazu factor homolog 1; hSF 1; NR5A1; Nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; POF7; SF 1; SF-1; SF1; SPGF8; SRXY3; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; Steroidogenic factor 1 nuclear receptor; STF 1; STF-1; STF1; STF1_HUMAN; |
| Description | Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 55 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |