ITA5125
ITA5125
- Catalog: ITA5125
- Gene/Protein: SP100
- Product Description: Immunotag™ SP100 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | SP100 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500~1:1000 IHC: 1:50~1:200, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide |
| Specificity | SP100 Antibody detects endogenous levels of total SP100 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | SP100 |
| Accession No. | P23497 |
| Alternate Names | DKFZp686E07254; FLJ00340; FLJ34579; Lysp100b; Nuclear antigen Sp100; Nuclear autoantigen Sp 100; Nuclear autoantigen Sp-100; Nuclear autoantigen Sp100; Nuclear dot associated Sp100 protein; Nuclear dot-associated Sp100 protein; SP 100; SP100; SP100 HMG nuclear autoantigen; SP100 nuclear antigen; SP100_HUMAN; Speckled 100 kDa; |
| Description | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 0 KD |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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