ITA5468
ITA5468
ITA5468
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$526.00
Price in reward points: 526
- Catalog: ITA5468
- Gene/Protein: USP30
- Product Description: Immunotag™ USP30 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein USP30 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IF/ICC,ELISA Recommended Dilution WB 1:500~1:1000, IF/ICC 1:100-1:500 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen A synthesized peptide Specificity USP30 Antibody detects endogenous levels of total USP30 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name USP30 Accession No. Q70CQ3 Alternate Names Deubiquitinating enzyme 30; FLJ40511; Ub-specific protease 30; Ubiquitin carboxyl terminal hydrolase 30; Ubiquitin carboxyl-terminal hydrolase 30; Ubiquitin specific peptidase 30; Ubiquitin specific processing protease 30; Ubiquitin thioesterase 30; Ubiquitin thiolesterase 30; Ubiquitin-specific-processing protease 30; UBP30_HUMAN; usp30; Description Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 60 KD Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
|
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | USP30 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500~1:1000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide |
| Specificity | USP30 Antibody detects endogenous levels of total USP30 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | USP30 |
| Accession No. | Q70CQ3 |
| Alternate Names | Deubiquitinating enzyme 30; FLJ40511; Ub-specific protease 30; Ubiquitin carboxyl terminal hydrolase 30; Ubiquitin carboxyl-terminal hydrolase 30; Ubiquitin specific peptidase 30; Ubiquitin specific processing protease 30; Ubiquitin thioesterase 30; Ubiquitin thiolesterase 30; Ubiquitin-specific-processing protease 30; UBP30_HUMAN; usp30; |
| Description | Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 60 KD |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |