ITA6417
ITA6417
ITA6417
from
$526.00
Price in reward points: 526
- Catalog: ITA6417
- Gene/Protein: RASSF1
- Product Description: Immunotag™ RASSF1 Antibody
-
Description
-
Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein RASSF1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC,ELISA Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen A synthesized peptide derived from human RASSF1 Specificity RASSF1 Antibody detects endogenous levels of total RASSF1 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name RASSF1 Accession No. Q9NS23 Alternate Names 123F2; Cardiac specific ras association domain family 1 protein; cardiac-specific ras association domain family 1 protein, 123F2; NORE2A; OTTHUMP00000195503; OTTHUMP00000195504; OTTHUMP00000195505; OTTHUMP00000195507; Pancreas specific ras association domain family 1 protein; Ras association (RalGDS/AF 6) domain family member 1; Ras association domain-containing protein 1; RASF1_HUMAN; Rassf1; RASSF1A; RDA32; REH3P21; Tumor suppressor protein RDA32; WUGSC:H_LUCA12.5; Description Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 39kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
|
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | RASSF1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human RASSF1 |
| Specificity | RASSF1 Antibody detects endogenous levels of total RASSF1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | RASSF1 |
| Accession No. | Q9NS23 |
| Alternate Names | 123F2; Cardiac specific ras association domain family 1 protein; cardiac-specific ras association domain family 1 protein, 123F2; NORE2A; OTTHUMP00000195503; OTTHUMP00000195504; OTTHUMP00000195505; OTTHUMP00000195507; Pancreas specific ras association domain family 1 protein; Ras association (RalGDS/AF 6) domain family member 1; Ras association domain-containing protein 1; RASF1_HUMAN; Rassf1; RASSF1A; RDA32; REH3P21; Tumor suppressor protein RDA32; WUGSC:H_LUCA12.5; |
| Description | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 39kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |