ITA6578
ITA6578
- Catalog: ITA6578
- Gene/Protein: TAP2
- Product Description: Immunotag™ TAP2 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | TAP2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human TAP2 |
| Specificity | TAP2 Antibody detects endogenous levels of total TAP2 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | TAP2 |
| Accession No. | Q03519 |
| Alternate Names | ABC transporter, MHC 2; ABC18; ABCB3; Antigen peptide transporter 2; APT2; ATP binding cassette, sub family B (MDR/TAP), member 3; ATP-binding cassette sub-family B member 3; D6S217E; Peptide supply factor 2; Peptide transporter involved in antigen processing 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF 2; PSF-2; PSF2; Really interesting new gene 11 protein; RING 11; RING11; TAP 2; Tap2; TAP2_HUMAN; Transporter 2 ATP binding cassette sub family B; Transporter 2, ABC (ATP binding cassette; Transporter 2, ATP binding cassette, sub family B (MDR/TAP); |
| Description | Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 76kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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