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ITA6765

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ITA6765
  • Gene/Protein: PADI4
  • Product Description: Immunotag™ PADI4 Antibody
280.0000
Price in reward points: 280

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Immunotag™ PADI4 Antibody
Antibody Specification
Datasheet

Target Protein PADI4
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC,IF/ICC,ELISA
Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
Concentration 1 mg/ml
Reactive Species Human,Rat
Host Species Rabbit
Immunogen A synthesized peptide derived from human PADI4
Specificity PADI4 Antibody detects endogenous levels of total PADI4
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name PADI4
Accession No. Q9UM07
Alternate Names EC 3.5.3.15; HL 60 PAD; HL-60 PAD; PAD 4; PAD; PADI 4; PADI 5; PADI H protein; Padi4; PADI4_HUMAN; PADI5; PDI 4; PDI 5; PDI4; PDI5; Peptidyl arginine deiminase type IV; Peptidyl arginine deiminase type V; Peptidylarginine deiminase IV; Protein arginine deiminase; Protein arginine deiminase type 4; Protein arginine deiminase type IV; Protein-arginine deiminase type IV; Protein-arginine deiminase type-4;
Description Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 74kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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