ITA6801
ITA6801
ITA6801
from
$526.00
Price in reward points: 526
- Catalog: ITA6801
- Gene/Protein: NDP
- Product Description: Immunotag™ NDP Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein NDP Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC,ELISA Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen A synthesized peptide derived from human NDP Specificity NDP Antibody detects endogenous levels of total NDP Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name NDP Accession No. Q00604 Alternate Names EVR2; Exudative vitreoretinopathy 2 (X linked); FEVR; ND; NDP; NDP_HUMAN; Norrie disease (pseudoglioma); Norrie disease protein; Norrin; Norrin precursor; X linked exudative vitreoretinopathy 2 protein; X-linked exudative vitreoretinopathy 2 protein; Description Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 15kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
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| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | NDP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human NDP |
| Specificity | NDP Antibody detects endogenous levels of total NDP |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | NDP |
| Accession No. | Q00604 |
| Alternate Names | EVR2; Exudative vitreoretinopathy 2 (X linked); FEVR; ND; NDP; NDP_HUMAN; Norrie disease (pseudoglioma); Norrie disease protein; Norrin; Norrin precursor; X linked exudative vitreoretinopathy 2 protein; X-linked exudative vitreoretinopathy 2 protein; |
| Description | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 15kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |