ITA6833
ITA6833
- Catalog: ITA6833
- Gene/Protein: CBLB
- Product Description: Immunotag™ CBLB Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | CBLB |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:500-1:2000 IHC 1:50-1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human CBLB |
| Specificity | CBLB Antibody detects endogenous levels of total CBLB |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | CBLB |
| Accession No. | Q13191 |
| Alternate Names | AI429560; AI851073; Cas Br M (murine) ecotropic retroviral transforming sequence b; Casitas B lineage lymphoma b; Casitas B lineage lymphoma proto oncogene b; Casitas B-lineage lymphoma proto-oncogene b; Cbl b; CBLB; CBLB_HUMAN; DKFZp686J10223; DKFZp779A0729; DKFZp779F1443; E3 ubiquitin protein ligase CBL B; E3 ubiquitin-protein ligase CBL-B; EC 6.3.2.-; FLJ36865; FLJ41152; Nbla00127; RING finger protein 56; RNF56; SH3 binding protein CBL B; SH3-binding protein CBL-B; Signal transduction protein CBL B; Signal transduction protein CBL-B; |
| Description | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 109kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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