ITA7540
ITA7540
- Catalog: ITA7540
- Gene/Protein: TXNIP
- Product Description: Immunotag™ TXNIP Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | TXNIP |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC,ELISA |
Recommended Dilution | WB 1:1000-3000 IHC 1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human TXNIP |
Specificity | TXNIP Antibody detects endogenous levels of total TXNIP |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | TXNIP |
Accession No. | Q9H3M7 |
Alternate Names | EST01027; HHCPA78; THIF; Thioredoxin binding protein 2; Thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; TXNIP; TXNIP_HUMAN; Upregulated by 1,25 dihydroxyvitamin D 3; VDUP1; Vitamin D3 up-regulated protein 1; |
Description | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 50 kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |