ITA7805
ITA7805
ITA7805
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$526.00
Price in reward points: 526
- Catalog: ITA7805
- Gene/Protein: PABPN1
- Product Description: Immunotag™ PABPN1 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein PABPN1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:1000-3000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen A synthesized peptide derived from human PABPN1 Specificity PABPN1 Antibody detects endogenous levels of total PABPN1 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name PABPN1 Accession No. Q86U42 Alternate Names Nuclear poly(A)-binding protein 1; OPMD; PAB2; PABII; PABP 2; pABP-2; PABP2; PABP2_HUMAN; PABPII; Pabpn1; poly(A) binding protein nuclear 1; Poly(A)-binding protein 2; Poly(A)-binding protein II; PolyA binding protein II; Polyadenylate-binding nuclear protein 1; Polyadenylate-binding protein 2; Description Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 49 kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
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| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | PABPN1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:1000-3000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human PABPN1 |
| Specificity | PABPN1 Antibody detects endogenous levels of total PABPN1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | PABPN1 |
| Accession No. | Q86U42 |
| Alternate Names | Nuclear poly(A)-binding protein 1; OPMD; PAB2; PABII; PABP 2; pABP-2; PABP2; PABP2_HUMAN; PABPII; Pabpn1; poly(A) binding protein nuclear 1; Poly(A)-binding protein 2; Poly(A)-binding protein II; PolyA binding protein II; Polyadenylate-binding nuclear protein 1; Polyadenylate-binding protein 2; |
| Description | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 49 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |