ITA7890
ITA7890
- Catalog: ITA7890
- Gene/Protein: RALA
- Product Description: Immunotag™ RALA Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | RALA |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC,ELISA |
Recommended Dilution | WB 1:1000-3000, IHC 1:50-1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human RALA |
Specificity | RALA Antibody detects endogenous levels of total RALA |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | RALA |
Accession No. | P11233 |
Alternate Names | MGC48949; Ral a; Ral A protein; RAL; RALA; RALA_HUMAN; Ras family small GTP binding protein RALA; RAS like protein A; Ras related protein RalA; Ras-related protein Ral-A; v ral simian leukemia viral oncogene homolog A (ras related); v ral simian leukemia viral oncogene homolog A; |
Description | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 24 kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |