ITA8347
ITA8347
ITA8347
from
$526.00
Price in reward points: 526
- Catalog: ITA8347
- Gene/Protein: PHLPP1
- Product Description: Immunotag™ SCOP Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein SCOP Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:1000-3000 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen A synthesized peptide derived from human SCOP Specificity SCOP Antibody detects endogenous levels of total SCOP Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name PHLPP1 Accession No. O60346 Alternate Names hSCOP; KIAA0606; PH domain and leucine rich repeat protein phosphatase; PH domain leucine rich repeat containing protein phosphatase; PH domain leucine rich repeat protein phosphatase; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; PHLP1_HUMAN; PHLPP; Phlpp1; Pleckstrin homology domain containing family E (with leucine rich repeats) member 1; Pleckstrin homology domain containing family E protein 1; Pleckstrin homology domain-containing family E member 1; PLEKHE 1 protein; PLEKHE1; SCN circadian oscillatory protein; SCOP; Suprachiasmatic nucleus circadian oscillatory protein; Suprachiasmatic nucleus circadian protein; Description Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 184 kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
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| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | SCOP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:1000-3000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human SCOP |
| Specificity | SCOP Antibody detects endogenous levels of total SCOP |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | PHLPP1 |
| Accession No. | O60346 |
| Alternate Names | hSCOP; KIAA0606; PH domain and leucine rich repeat protein phosphatase; PH domain leucine rich repeat containing protein phosphatase; PH domain leucine rich repeat protein phosphatase; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; PHLP1_HUMAN; PHLPP; Phlpp1; Pleckstrin homology domain containing family E (with leucine rich repeats) member 1; Pleckstrin homology domain containing family E protein 1; Pleckstrin homology domain-containing family E member 1; PLEKHE 1 protein; PLEKHE1; SCN circadian oscillatory protein; SCOP; Suprachiasmatic nucleus circadian oscillatory protein; Suprachiasmatic nucleus circadian protein; |
| Description | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 184 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |