ITA8456
ITA8456
ITA8456
from
$526.00
Price in reward points: 526
- Catalog: ITA8456
- Gene/Protein: RIOK3
- Product Description: Immunotag™ RIOK3 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein RIOK3 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IF/ICC,ELISA Recommended Dilution WB 1:1000-3000, IF/ICC 1:100-1:500 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen A synthesized peptide derived from human RIOK3 Specificity RIOK3 Antibody detects endogenous levels of total RIOK3 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name RIOK3 Accession No. O14730 Alternate Names Homolog of the Aspergillus nidulans sudD gene product; RIO kinase 3 (yeast); RIO kinase 3; RIOK3; RIOK3_HUMAN; Serine/threonine protein kinase RIO3; Serine/threonine-protein kinase RIO3; SudD (suppressor of bimD6, Aspergillus nidulans) homolog; SUDD; sudD homolog; SudD suppressor of Aspergillus nidulans bimD6 homolog; SudD suppressor of bimD6 homolog; Description Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 59 kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
|
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | RIOK3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:1000-3000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human RIOK3 |
| Specificity | RIOK3 Antibody detects endogenous levels of total RIOK3 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | RIOK3 |
| Accession No. | O14730 |
| Alternate Names | Homolog of the Aspergillus nidulans sudD gene product; RIO kinase 3 (yeast); RIO kinase 3; RIOK3; RIOK3_HUMAN; Serine/threonine protein kinase RIO3; Serine/threonine-protein kinase RIO3; SudD (suppressor of bimD6, Aspergillus nidulans) homolog; SUDD; sudD homolog; SudD suppressor of Aspergillus nidulans bimD6 homolog; SudD suppressor of bimD6 homolog; |
| Description | Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 59 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |