ITA8815
ITA8815
ITA8815
from
$526.00
Price in reward points: 526
- Catalog: ITA8815
- Gene/Protein: ALKBH7
- Product Description: Immunotag™ ALKBH7 Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein ALKBH7 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,IHC,ELISA Recommended Dilution WB 1:1000-3000 IHC 1:200 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen A synthesized peptide derived from human ALKBH7 Specificity ALKBH7 Antibody detects endogenous levels of total ALKBH7 Purification The antiserum was purified by peptide affinity chromatography. Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt Gene Name ALKBH7 Accession No. Q9BT30 Alternate Names ABH7; ALKB7_HUMAN; ALKBH7; Alkylated DNA repair protein alkB homolog 7; MGC10974; Probable alpha-ketoglutarate-dependent dioxygenase ABH7; SPATA11; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11; UNQ6002; UNQ6002/PRO34564; Description May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). Cell Pathway/ Category Primary Polyclonal Antibody Protein MW 24 kDa Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet |
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| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | ALKBH7 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:1000-3000 IHC 1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human ALKBH7 |
| Specificity | ALKBH7 Antibody detects endogenous levels of total ALKBH7 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | ALKBH7 |
| Accession No. | Q9BT30 |
| Alternate Names | ABH7; ALKB7_HUMAN; ALKBH7; Alkylated DNA repair protein alkB homolog 7; MGC10974; Probable alpha-ketoglutarate-dependent dioxygenase ABH7; SPATA11; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11; UNQ6002; UNQ6002/PRO34564; |
| Description | May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 24 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |