ITA8921
ITA8921
- Catalog: ITA8921
- Gene/Protein: AFF4
- Product Description: Immunotag™ AFF4 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | AFF4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:1000-3000 IHC 1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human AFF4 |
| Specificity | AFF4 Antibody detects endogenous levels of total AFF4 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | AFF4 |
| Accession No. | Q9UHB7 |
| Alternate Names | AF4/FMR2 family member 4; AF5Q31; Alf4; ALL1 fused gene from chromosome 5q31; HSPC092; Laf4; Lymphoid nuclear protein related to AF4 like; Major CDK9 elongation factor associated protein; MCEF; MGC107469; RP23-226J16.7; |
| Description | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 127kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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