ITA9186
ITA9186
- Catalog: ITA9186
- Gene/Protein: APOBEC3H
- Product Description: Immunotag™ APOBEC3H Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | APOBEC3H |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:1000-3000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human APOBEC3H |
Specificity | APOBEC3H Antibody detects endogenous levels of total APOBEC3H |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | APOBEC3H |
Accession No. | Q6NTF7 |
Alternate Names | A3H; APOBEC related protein 10; APOBEC3H; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3H; ARP 10; DNA dC->dU-editing enzyme APOBEC-3H; |
Description | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 24 kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |